NCI Analysis Tools
CCR - Center for Cancer Research
CBIIT - CGBB (Computational Genomics & Bioinformatics Branch)
CGH - Center for Global Health
DCCPS – Division of Cancer Control and Population Sciences
DCEG – Division of Cancer Epidemiology and Genetics
This toolset estimates risk stratification from early biomarker data and includes math and strategies to advance biomarkers or other risk measures identified case-control studies to clinical or public health applications. The toolset will show quantities for which people's intuition is poor, such as need for high specificity for a single marker of a rare disease to improve management by some serious intervention.
The toolset will allow to evaluate the feasibility of biomarkers called promising before they get press office attention; investigators spend efforts on hopeless pursuit; wasteful. unethical clinical testing begins. Thus, using these strategies will allow focusing on the most promising markers early on, making specific improvements if required, or abandoning markers that are most likely to fail.